Jacob uses genomics and machine learning methods to identify and manipulate the genetic programs that define cell identity. Prior to NewLimit, Jacob led a research laboratory focused on epigenetic reprogramming as a Principal Investigator and Computational Fellow at Calico. His program developed methods to infer and perturb cell identity programs and leveraged these tools to discover reprogramming strategies that restore youthful features in aged cells. Jacob received a Ph.D. in stem cell biology from the University of California San Francisco.