Brendan Frey is an internationally acclaimed entrepreneur, engineer and scientist. He made fundamental contributions in the fields of deep learning, genomic medicine, and information technology. His work with Geoffrey Hinton on the 'wake-sleep algorithm' helped to launch the field of deep learning (Science 1995). Brendan is a pioneer in developing AI systems that could accurately predict normal and pathological cell and genome biology, facilitating biomedical breakthroughs. He co-authored over 200 papers, including over a dozen that appeared in Nature, Science, and Cell. This work led to the discovery of new biology, the founding of Deep Genomics in 2015.