Akihiro Ishiguro is Head of the PMDA Washington D.C. Office. Since joining the Pharmaceuticals and Medical Devices Agency (PMDA) in 2004, he has contributed to post-marketing drug safety, new drug review, and regulatory science. He has led initiatives in pharmacokinetics and clinical pharmacology, including international guideline development through the International Council for Harmonisation (ICH). Since 2017, he has served as a review leader and principal investigator for a Japan Agency for Medical Research and Development (AMED) project, and as regulatory chair of the ICH M12 Expert Working Group. He now promotes U.S.–Japan regulatory collaboration and supports U.S.-based startups entering the Japanese market.