ACT EU focuses on optimizing the European clinical trials environment, strengthening clinical trials that provide decisional evidence, delivering excellent, coordinated scientific advice, and engaging all stakeholders to proactively deliver inclusive patient-oriented medicines. The EU regulatory network under Accelerating Clinical Trials in the EU (ACT EU) is leading the transformation initiative with innovation and modernization of the environment facilitating planning, initiation, design, and conduct of clinical trials. The aim is to further develop the EU as a focal point for clinical research, promote the development of high-quality, safe and effective medicines, and better integrate clinical research in the European health system. ACT EU will also ensure a unified EU position on clinical trials in strategic matters at international level and build capacity in drug development and regulatory science.