Equitable access to clinical trials is integral to achieving health equity. Clinical research contributes to scientific knowledge for treatment options that may potentially benefit patients, providers, and the broader research community in the future. Therefore, it is critical that clinical trials are conducted without bias and include participation representative of patients who are afflicted with the disease being studied. This session will present current patient - and RWD - driven strategies being considered and operationalized from multiple stakeholders driven to enroll clinical trials that better reflect the populations impacted by given diseases.