New Approach Methodologies (NAMs) are at the forefront of transforming how biomedical research translates into real-world treatments, enabling faster and more precise drug development by, in some cases, bypassing traditional animal models. This session will explore the pivotal role NAMs play in advancing translational research, effectively bridging the gap between laboratory discoveries and clinical applications. Participants will gain a comprehensive understanding of how NAMs are reshaping the journey from basic research to regulatory testing, offering a more ethical, efficient, and scientifically robust pathway to safer and more effective therapies.