As gene editing and epigenetics evolve, they are not only transforming how we approach complex diseases but also unlocking new possibilities for enhancing longevity, healthspan, and even organ transplantation. These advancements offer the potential to treat conditions such as obesity, extend lifespan, and overcome organ shortages by developing genetically-engineered porcine organs. With these technologies moving beyond the lab, they hold promise for revolutionizing therapies and improving overall health, paving the way for longer, healthier lives and more effective treatments for a range of chronic conditions. This panel will explore the real-world applications of these groundbreaking technologies, highlighting their role in developing therapies for genetic disorders, obesity, age-related diseases, and organ transplantation. From CRISPR-based gene editing to innovative epigenetic strategies, speakers will discuss how these tools are being used to precisely regulate gene expression, target disease pathways, and create genetically engineered organs for transplantation.