Mote Therapeutics Inc.
June 16, 2025
Company Presentation

We are a seed-stage biotech solving targeted delivery of mRNA-based medicines. mRNA has achieved breakthrough success with COVID vaccines, but access to most disease-relevant tissues and cell types remains an unresolved challenge with current mRNA delivery systems. Engineering next-generation delivery systems therefore holds enormous promise for expanding the application space of mRNA into novel therapeutic areas. A new wave of mRNA delivery-focused companies such as Capstan and Aera Therapeutics have entered this exciting space with targeted delivery solutions that lack modularity or are very challenging to scale. At Mote, we have created the Mobilize technology platform: a scalable, modular, and effective LNP based targeted mRNA delivery solution proven in vivo (in mice and NHP) to both actively target nanoparticles to cells of interest and prevent uptake in unintended targets.

Company HQ City:
Lexington
Company HQ State:
MA
Company HQ Country:
United States
Year Founded:
2023
Lead Product in Development:
in situ CAR-T for CD19 positive B cell malignancies
CEO
CEO: Roc Cui
COO: Wei Xiao
Development Phase of Lead Product
Pre-Clinical
What is your next catalyst (value inflection) update?
mid-2025: NHP efficacy data
Primary Speaker