The rapid advancement of DNA foundation models is transforming our ability to decode complex genomic patterns and regulatory mechanisms. This session will explore the current state of these models, their applications in drug discovery, and future directions for the field. Panelists will present specific use cases in the drug discovery workflow, examining how these models can accelerate discoveries in areas ranging from development biology to personalized medicine, while sharing insights into the technical performance of foundation models and their implications for biological and clinical research. Attendees will also hear about the promising avenues for future exploration that can foster and facilitate the wider adoption of these innovative tools in genomics.