Xsphera Biosciences
- Biotech or pharma, therapeutic R&D
- Other R&D services
- CMO, CRO
- Other products or services
Xsphera Biosciences is transforming oncology drug development by replacing animal models with an ex vivo platform that directly measures therapeutic responses in fresh human tumor tissues. We use PDOTS (Patient-Derived Organotypic Tumor Spheroids), a patented technology from Dana-Farber Cancer Institute, to preserve each patient’s tumor microenvironment—immune cells, stromal components, and all—within a 3D microfluidic system, enabling highly predictive insights. Our integrated biology and cloud analytics platform provides direct access to cytotoxicity, gene/protein expression, and AI-powered visualizations. With experience across 10+ cancer types and modalities including targeted therapy, immunotherapy, cell therapy, and ADCs,
Xsphera helps
- Identify optimal lead compounds, combinations, and target indications
- Understand MOA/MOR
- Discover biomarkers for patient stratification
- Reduce reliance on animal models—saving time, cost, and ethical burden
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