Sculpta Bio
- Biotech or pharma, therapeutic R&D
Sculpta is a Stanford spinout pioneering a new approach to RNA therapeutics for neurodegenerative and psychiatric diseases. Unlike conventional gene therapies that simply alter gene expression levels, Sculpta rewires alternative RNA splicing to precisely reshape the structure and function of disease-causing proteins in the brain—an approach we call protein sculpting. This approach enables us to make precision changes to specific protein domains to alter enzyme kinetics, protein localization, and individual binding partners. Our platform integrates best-in-class human brain organoids (featured in Nature, Cell, Science), innovations enabling scalable full length RNA-sequencing from single cells, and an AI-driven RNA splicing target detection platform to identify and validate novel targets inaccessible with traditional methods.
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