Fathom Therapeutics, Inc.

Fathom Therapeutics is a preclinical-stage company that uses quantum chemistry and AI to design novel drug molecules by predicting their behavior inside living cells. The design approach precisely modulates protein complexes to achieve defined biological outcomes. Fathom Therapeutics’s discovery engine, Microcosmos, uses proprietary algorithms to simulate protein motion at atomic resolution, generating data on dynamic behavior and driving design of functional therapeutic molecules. This powers discovery across multiple modalities, including inhibitors, molecular glues, allosteric regulators, heterobifunctional stabilizers, and targeted protein degraders that remain largely inaccessible to conventional approaches. In less than three years since its founding, Fathom has established 12 partnerships that successfully improved our partners’ decision-making in asset pipeline programs, and demonstrated broad applicability of Microcosmos across targets, modalities, and disease areas.