Alzheimer’s disease is one of the greatest challenges facing patients, health systems, and society, affecting over 55 million people worldwide. At the intersection of a growing public health crisis, capital pressures, and profound economic burden, the field is at a pivotal inflection point. Addressing it will require diversified investment strategies and cross-sector collaboration that accelerate scientific progress across the full research and development continuum. This panel convenes leaders from biotech, pharma, and philanthropy to examine how innovative science, strategic investment, and collaborative models can unlock the next wave of Alzheimer’s breakthroughs and accelerate progress toward conquering this disease once and for all.