Our industry has faced a variety of geopolitical and economic issues that inject uncertainty into deal-making. We must now navigate an unprecedented wave of legislation, executive orders, and policies covering most favored nation pricing, tariffs, data sharing restrictions, and domestic manufacturing, among others. In this panel, speakers will explore strategies for how to allocate risk and close deals in the face of this uncertainty. These dynamics require organizations to adopt more agile negotiation frameworks, strengthen interdisciplinary collaboration, and anticipate shifting regulatory interpretations, ensuring that transactions remain resilient, competitive, and aligned with rapidly evolving global expectations as well as commercial realities and pressures.