This panel discussion addresses a critical paradox in biotechnology investment - while female-founded biotech’s demonstrate superior returns, they receive less than 3% of venture funding. This session features four pioneering founders currently building transformative "zero-to-one" companies - those creating entirely new market categories rather than competing in existing spaces. Panelists represent diverse biotech innovations spanning hibernation-based therapeutics, non-invasive vital sign monitoring, epigenetic gene therapies, and gravity-agnostic biotools. This session provides data-driven insights into the funding landscape while delivering actionable strategies for investors, a roadmap from the bench to the boardroom for scientists, understanding emerging technologies that could disrupt traditional approaches for industry veterans, and tactical advice to entrepreneurs from fellow founders building in the hardest environment.